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Tripartite drug vehicles include a targeting component (blue spheres) called an axonal transport facilitator (ATF), a long chain polymer such as dextran (red molecular chain), and numerous drug molecules attached to the polymer (yellow molecules). The drawing represents carriers wich actually can carry more than a hundred drug molecules in each tripartite complex. Complexes adhere to molecule in the synaptic membrane and are then carried in the axonal transport stream, along the microtubules, to reach the cell body. |
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